Isibizo: 4-Aminobutyric acid
Umsuka: I-Fermentation biosynthesis
Ukucaciswa: 99%γ-GABA
Izinzuzo: Imininingwane eyenziwe ngokwezifiso; I-bioavailability ephezulu; Ukuzinza okuhle kokukhanya; Intengo yokuncintisana
Ukubukeka: I-crystalline powder emhlophe
Indlela yokutholwa: HPLC
CAS: 56-12-2
Ifomula yemolekyuli: C4H9NO2
Isisindo samangqamuzana: 103.12g/mol
Ifomula yekhemikhali:
I-Gamma Aminobutyric Acid (GABA), eyaziwa nangokuthi i-4-aminobutyric acid kanye ne-aminobutyric acid, iyi-amino acid engeyona amaprotheni esebenzayo ekhona ngokwemvelo emzimbeni womuntu. Kuyi-neurotransmitter ebalulekile evimbela ohlelweni lwezinzwa olumaphakathi lwezilwane ezincelisayo. Cishe u-30% wama-synapses emizwa emaphakathi asebenzisa i-GABA njengesidlulisi. Idlala indima ebalulekile ku-human cerebral cortex, i-hippocampus, i-thalamus, i-basal ganglia kanye ne-cerebellum. Inemisebenzi ebaluleke kakhulu yomzimba. Ingathuthukisa ukusebenza kobuchopho, ithuthukise ukulala, idambise imizwelo, inhle futhi imanzise isikhumba, futhi ibambezele ukuguga kobuchopho.
Ukuzinza okushisayo kwe-GABA kubi kakhulu. Ngemuva kokuphathwa ku-100 ℃ imizuzu engu-20, okuqukethwe kwe-GABA kwehla cishe ngo-59.2%, okukhawulela kakhulu ukusetshenziswa kwe-GABA emkhakheni wokudla. I-HiHealth isebenzisa ukuvutshelwa kwe-microbial kuhlanganiswe nobuchwepheshe bokushumeka ukulungisa i-GABA, okuyenza ibe nokuzinza okungcono kokushisa futhi yandise ukusetshenziswa kwe-GABA eziphuzweni, amaswidi athambile namanye amafomu omthamo.
1.Usizo lokulala
Umfanekiso 1
Umfanekiso 2
Umfanekiso 3
Umfanekiso 1 kanye noMfanekiso 2: Imiphumela yokuhlolwa kwe-EEG. Amanani ayincazelo±SD yezinguquko ekubambezelekeni kokulala (A)kanye nesikhathi sokulala esingesona i-REM esiphelele (E)
Umfanekiso 3: Uhlu lwemibuzo lwe-VAS kanye nemiphumela ye-PSQI. Amanani asho ±SD wezinguquko kunani le-VAS ngokuphathelene nokwaneliseka kokulala, imizwa lapho uvuka, ukulala kalula (A)
I-γ-aminobutyric acid (i-GABA) ifinyeze ngokuphawulekayo ukubambezeleka kokulala futhi yandisa ingqikithi yesikhathi sokulala esingasheshi (non-REM) sokulala. Uhlu lwemibuzo lubonise ukuthi izifundo ezithola i-GABA zabona imiphumela yayo ebuthongweni.
2.Yehlisa ukukhathazeka
I-GABA inyusa kakhulu amagagasi e-alpha futhi yehlisa amagagasi e-beta uma kuqhathaniswa namanzi noma i-L-theanine. Lokhu okutholakele kubonisa ukuthi i-GABA ayigcini nje ngokubangela ukuphumula kodwa futhi yehlisa ukukhathazeka.
3.Yehlisa ingcindezi engokwengqondo
Kusukela ekushintshashintsheni kwesilinganiso senhliziyo (HRV), labo abathatha ushokoledi we-γ-aminobutyric (GABA) benze ukululama ngokushesha kuya esimweni esivamile kusukela esimweni sokucindezeleka. Inani le-chromogranin A (CgA) ngemva komsebenzi kulabo abathatha ushokoledi we-GABA alizange likhuphuke uma liqhathaniswa nalelo ngaphambi kokumunywa. Kusukela kule miphumela, ushokoledi we-GABA wawubhekwa njengomphumela wokunciphisa ukucindezeleka kwengqondo.
4.Ukuphatha isisindo
Ukwengeza nge-GABA kunganciphisa ukukhuluphala kanye nokunqwabelana kwamafutha kumagundane, futhi kunezinto ezibalulekile zokulwa nokukhuluphala.
5.Yehlisa izifo zobuchopho zesimiso sezinzwa
I-Plasma γ -aminobutyric acid (GABA) yayihlotshaniswa kahle nemiphumela yokucindezeleka nokunganaki ku-Neuropsychiatric Inventory futhi ihlotshaniswa kabi neminyaka.Izigaba zokugcina zesifo se-Alzheimer zihlotshaniswa noshintsho lwe-GABAergic.
6.Yehlisa ushukela egazini
Imithelela kabhontshisi we-adzuki ohlume ocebile we-GABA kumaka we-serum we-glucose metabolism kumagundane ane-T2DM. Amanani amelela isilinganiso ± SEM (n ≥ 5); (A) FBG; (B) INS. Amanani anezimpawu ezihlukene ahluke kakhulu (p
Ukudla okuphezulu kwe-GABA-rich ehluma ubhontshisi we-adzuki kwehlisa kakhulu amazinga e-serum e-FBG. I-γ-aminobutyric acid (GABA) ibe nomthelela wokuvimbela ku-glycolipid metabolism kumagundane anesifo sikashukela sohlobo lwe-2 mellitus (T2DM).
