"Special Symptoms" That Appear In The Body After Taking NMN

Changes in energy metabolism

NMN may also have an effect on the overall metabolic rate. By improving mitochondrial function and promoting cellular energy metabolism, the body's basal metabolic rate may increase. This means that the body can consume more energy even at rest, which helps maintain a normal body weight or promote weight loss. For example, in some animal experiments, animals taking NMN gained weight more slowly than those not taking it, probably because their metabolic rate increased, fat decomposition and energy expenditure increased.

Blood vessel improvement

NMN has a positive effect on vascular endothelial cells. It can increase the level of NAD⁺ in vascular endothelial cells, activate SIRT1 (a NAD⁺-dependent deacetylase), and then promote the activity of endothelial nitric oxide synthase (eNOS). eNOS can catalyze the production of nitric oxide (NO), which is an important vasodilator factor that can dilate blood vessels, lower blood pressure, and improve blood circulation. In some small human trials, an increase in vascular elasticity and a certain degree of downward trend in blood pressure were observed after taking NMN. At the same time, NMN may also help reduce the risk of atherosclerosis because it can improve endothelial function, reduce inflammatory responses and oxidative stress, and inhibit platelet aggregation.

Improved nervous system function

In the brain, NMN is able to cross the blood-brain barrier and provide support to nerve cells. Higher NAD⁺ levels can activate signaling pathways associated with neuroprotection and neuroplasticity. For example, by activating SIRT1, NMN may be involved in regulating gene expression in nerve cells, promoting the proliferation and differentiation of neural stem cells, and contributing to the repair and regeneration of neural tissue. In some cognitive function tests, animals or people taking NMN may show improvements in memory, attention, and learning ability. For patients with neurodegenerative diseases (such as Alzheimer's disease and Parkinson's disease), NMN may also delay the progression of the disease by improving mitochondrial function, reducing oxidative stress and neuroinflammation.

Reduced anti-inflammatory response

NMN can inhibit the activation of inflammatory signaling pathways. For example, it can inhibit the NF-κB (nuclear factor κB) signaling pathway by activating SIRT1, reducing the production and release of inflammatory factors (such as interleukin-6, tumor necrosis factor-α, etc.). In some inflammation-related disease models, taking NMN can reduce inflammatory responses and alleviate disease symptoms. For example, in intestinal inflammation, NMN may promote intestinal health by reducing inflammatory responses and improving intestinal barrier function.

Possible side effects

Gastrointestinal discomfort

Symptoms: abdominal pain, diarrhea, nausea, vomiting, etc., which may involve the entire digestive system.

Cause: NMN may irritate the gastrointestinal tract, leading to excessive gastric acid secretion or accelerated gastrointestinal motility.

Skin reactions

Symptoms: redness, itching, rash, etc., usually appearing at the site of exposure to NMN.

Cause: It may be related to the individual's sensitivity to NMN, i.e., NMN irritates or causes allergic reactions to the skin

Mood changes

Symptoms: changes in psychological state such as anxiety, depression, irritability, etc.

Causes: NMN can affect neurotransmitters in the brain, thereby affecting emotional state.

Insomnia

Symptoms: Long-term intake of NMN may cause the nerves to be in an excited state, causing insomnia or unstable sleep.

Causes: NMN may increase the secretion of dopamine in the body.

Malnutrition

Symptoms: Long-term excessive intake of NMN may lead to malnutrition and affect overall health.

Causes: NMN may promote excessive consumption of fat and sugar in the body.

Allergic reaction

Symptoms: For people with sensitive constitutions, long-term consumption of NMN may cause allergic reactions, such as skin itching, redness, swelling, rash, etc. In severe cases, severe allergic symptoms such as difficulty breathing may occur.

Abnormal sex hormone levels

Symptoms: Enhanced sexual function, vigorous hair growth, etc.

Causes: After NMN enters the human body, it may participate in cell metabolism, leading to increased sex hormone levels in the body.

Damage to liver and kidney function

Symptoms: Long-term and large-scale intake of NMN may increase the burden on the liver and kidneys, leading to damage to liver and kidney function.

Causes: NMN is mainly metabolized and excreted through the liver and kidneys.

Other potential risks

Symptoms: hypoglycemia (dizziness, fatigue), acne, internal heat and other adverse reactions.

Causes: It may be related to certain components in NMN or individual differences in NMN metabolism.