"King of Anti-Aging"

Benefits of Ergothioneine

1. Antioxidant Activity

Activates antioxidant enzymes (SOD and GPx) to neutralize free radicals (e.g., hydroxyl radicals, singlet oxygen).  

Its small molecular structure penetrates cell membranes, protecting mitochondrial function and delaying oxidative stress-induced cell damage. Outperforms traditional antioxidants like vitamin C.  

2. Anti-Aging Effects

Inhibits matrix metalloproteinases (MMPs) to reduce collagen breakdown and boosts collagen (Type I/III) gene expression, improving skin texture.  

Enhances telomerase activity to slow cellular aging. Clinical trials show 18% reduction in fine line depth after 8 weeks of use.  

3. Anti-Inflammatory & Repair

Blocks NF-κB signaling to suppress pro-inflammatory cytokines (IL-6, TNF-α) and balances Th1/Th2 immunity, alleviating rosacea and UV-induced inflammation.  

Strengthens skin barrier by promoting synthesis of filaggrin and loricrin, accelerating epidermal repair.  

4. Metabolic Regulation

Acts as a substrate for mitochondrial OCTN1 transporter, enhancing ATP production via the TCA cycle and electron transport chain.  

Animal studies reveal 15-20% increased exercise endurance and improved glucose/lipid metabolism via AMPK activation, showing potential for metabolic syndrome.  

Precautions

1. Avoid during pregnancy/lactation: Insufficient clinical data on fetal safety. In vitro studies confirm placental transfer; potential risks require strict avoidance.  
2. Patch test for sensitive skin: Apply behind the ear or inner forearm for 3 days. Sulfur allergies may trigger contact dermatitis (0.3% incidence); discontinue if redness occurs.  
3. Avoid combining with high-acid products: Degrades at pH <3.5. Bioavailability drops by 62% when paired with >10% glycolic acid or >20% salicylic acid. Use with a 2-hour interval.  
4. Light-sensitive storage: UV exposure (especially UVA) induces photoisomerization. Use opened products within 30 days. Unopened items should be refrigerated (2-8°C); avoid transparent packaging.