Kev ua haujlwm ntawm Boswellia Extract-Boswellic Acid
1.Anti-inflammatory, antibacterial
Ib qho kev tshawb nrhiav ob qhov muag tsis pom kev ntawm kev ua tau zoo ntawm frankincense extract ntawm adjuvant-induced mob caj dab nas pom tau hais tias frankincense extract muaj cov tshuaj tiv thaiv kab mob tseem ceeb, thiab nws cov txheej txheem yuav cuam tshuam rau inhibition ntawm kev tsim cov cytokines pro-inflammatory. Liu Xiangyun et al. tau kawm txog cov tshuaj tiv thaiv kab mob ntawm frankincense thiab frankincense acid, uas tau siv rau hauv kev kho mob ntawm cov mob rheumatoid mob caj dab, nrog tus nqi zoo ntawm 95% thiab kho tus nqi ntawm 85%.
Daim duab 3 qhia tau hais tias BA cuam tshuam qhov mob paw edema evoked los ntawm kev txhaj tshuaj carrageenan los ntawm kev siv tshuaj pleev ib ce. Cov ntaub ntawv los ntawm BA kho tsiaj nrog koob tshuaj ntawm 1.25, 2.5 thiab 3.75 mg / paw (ib daim ntawv thov) ntawm lub sijhawm sib txawv tau pom qhov sib txawv ntawm cov paw edema piv rau lub tsheb kho tsiaj tib lub sijhawm. Cov txiaj ntsig ntawm tib koob tshuaj nrog ob daim ntawv thov ntawm BA pom zoo inhibition ntawm paw o. Ib yam li ntawd, thaum BA thov 45 min ua ntej thiab 1, 2 thiab 3 h tom qab txhaj tshuaj carrageenan cov nyhuv yog qhov tseem ceeb tshaj li ob qho xwm txheej thaum ntxov (Fig. 4).
2. Kho mob plab rwj
Cov kev tshawb fawb soj ntsuam niaj hnub no tau pom tias frankincense extract tuaj yeem txhim kho qhov zoo ntawm cov kab mob regenerated mucosal hauv cov nas uas muaj kab mob plab; txo cov infiltration ntawm neutrophils, lymphocytes, plasma hlwb, monocytes thiab macrophages nyob rau hauv lub lamina propria ntawm regenerated mucosa ntawm nas nrog gastric ulcers, thiab txhim kho qhov zoo ntawm regenerated mucosal qauv nyob rau hauv nas nrog gastric ulcers; Nws muaj cov txiaj ntsig ntawm kev ua kom lub zais ntawm cov mucous nruab nrab los ntawm cov hlwb regenerated mucosal, thiab txhim kho kev ua haujlwm kom loj hlob ntawm cov kab mob regenerated mucosa hauv cov nas uas muaj kab mob plab.
Cov txiaj ntsig ntawm txoj kev tshawb fawb tam sim no tau qhia tias BA muaj cov tshuaj tiv thaiv kab mob tiv thaiv kab mob sib txawv. Nws pom tau tias qhov sib txawv ntawm qhov inhibition ntawm tus kab mob rwj ntawm cov kab mob ulcerogenic sib txawv. Cov qhab nia ntawm qhov txhab tawm tsam ntau yam kab mob ua rau cov neeg ua haujlwm viz., pyloric ligation, ethanol / HCl, (mob thiab mob ntev) acetylsalicylic acid, indomethacin thiab kev ntxhov siab txias, yog inhibited los ntawm 39%, 38%, 51%, 31%, 37% thiab 42% feem ntawm mg / kg.
3.Anti-mob
Frankincense acid tebchaw thiab volatile roj nyob rau hauv frankincense muaj kev tiv thaiv qog nqaij hlav xws li inhibiting qog cell proliferation, inducing cell txawv thiab apoptosis.
Monotherapy nrog boswellic acids (250 thiab 500 mg / kg / hnub) ua rau muaj qhov hnyav ntawm EAC cov qog nqaij hlav (≈ 46 thiab 48% txo, raws li) piv rau pawg tswj hwm EAC. Morover, kev sib xyaw ua ke ntawm doxorubicin nrog boswellic acids ntawm ntau koob tshuaj (125, 250 thiab 500 mg / kg / hnub) ua rau txo qhov loj ntawm EAC khoom qog piv nrog EAC tswj pawg, doxorubicin pawg nrog rau boswellic acids coj cov tshuaj monotherapy (Fig. 1A).
4. Txhim kho kev nco
β-Boswellic acid tuaj yeem txhawb txoj kev loj hlob thiab cov ceg ntawm hippocampal neuron synapses, txhim kho kev loj hlob, branching thiab microtubule polymerization dynamics ntawm paj hlwb axons, thiab yog li txhim kho kev nco. Karima et al. cov kev tshawb fawb tau qhia tias kev ntxiv dag zog rau cov nyhuv ntawm microtubule polymerization dynamics yuav yog lub hauv paus ntawm β-boswellic acid nce axon kev loj hlob thiab branching. Lawv yuav ua kev tshawb fawb ntxiv txog nws txoj haujlwm nyuaj hauv cov hlab ntsha kom paub meej tias kev txhim kho kev nco los ntawm β-boswellic acid.
Txoj kev tshawb no tau tshawb xyuas qhov cuam tshuam ntawm boswellic acid ntawm kev kawm spatial thiab kev nco tsis zoo uas tshwm sim los ntawm trimethyltin (TMT) hauv Wistar nas. Kev kho mob nrog TMT tsis muaj kev kawm thiab kev nco, thiab kev kho mob nrog BA ntawm koob tshuaj ntawm 160 mg / kg ua rau muaj kev txhim kho tseem ceeb hauv kev kawm thiab kev nco muaj peev xwm hauv dej maze cov dej num.
Kev daws ntawm Boswellia Extract-Boswellic Acid
