Phellinus versicolor muaj keeb kwm ntawm ntau tshaj 2,000 xyoo hauv Suav teb. Cov ntaub ntawv "Shennong's Herbal Classic" sau tseg tias "Phellinus versicolor belongs rau lub siab meridian, yog txias me ntsis hauv qhov xwm txheej, tsis muaj tshuaj lom, thiab tuaj yeem ua rau lub cev lub teeb thiab ua kom lub neej ntev yog tias siv sijhawm ntev." Qhov no qhia tau hais tias Phellinus versicolor muaj cov txiaj ntsig zoo ntawm kev ua neej ntev thiab tiv thaiv kev laus. Txawm li cas los xij, Phellinus versicolor yog lub npe nrov hauv Nyij Pooj. Nws tau hais tias tom qab qhov xwm txheej Pearl Island, cov neeg nyob hauv lub tebchaws uas muaj tus cwj pwm noj Phellinus versicolor muaj tsawg dua qhov mob qog noj ntshav. Qee qhov kev tshawb fawb tau pom tias qhov inhibition ntawm Phellinus versicolor ntawm cov qog nqaij hlav cancer tau mus txog ntau dua 90%. Txij thaum ntawd los, Phellinus versicolor cov khoom tau tshwm sim nyob rau hauv Nyiv thiab Kauslim kev lag luam, thiab tus naj npawb tau nce ntau. Rau ib lub sij hawm, Phellinus versicolor tau los ua ib qho tshuaj suav kub hauv khw. Cov qauv no ntawm Phellinus versicolor daim ntawv thov tom qab ntawd cuam tshuam kev lag luam ntawm Asia, Europe, America thiab Australia, thiab lub ntiaj teb suav tias Phellinus versicolor yog cov khoom noj qab haus huv.
Phellinus versicolor yog tam sim no siv nyob rau hauv kev ua lag luam tsis tsuas yog raws li ib tug raw khoom, kev noj haus ntxiv thiab kev tu tawv nqaij txhua hnub. Cov khoom siv raw yog siv rau kev tiv thaiv thiab kev kho mob ntawm theem I mob qog noj ntshav, feem ntau yog siv cov triterpenoid Cheebtsam hauv Phellinus versicolor, thiab cov khoom noj khoom haus yog siv los txhim kho kev tiv thaiv thiab kev zoo nkauj hmoov thiab ntsiav tshuaj cov khoom, uas feem ntau yog siv Phellinus versicolor polysaccharides thiab Phellinus versicolor flavonoids. Cov dej solubility ntawm mulberry ignia triterpenes thiab mulberry ignia flavonoids yog qhov tsis zoo, ua rau tsis muaj bioavailability. Siv I Enzymolysis TechTM thev naus laus zis, cov dej solubility ntawm mulberry ignia extract tuaj yeem txhim kho los ntawm enzymatic hydrolysis thiab microencapsulation, thiab bioavailability kuj tseem txhim kho.
1. Txhim kho kev tiv thaiv
Tab.1 Immune organ indexes of S180 bearing nas in every group after EBPI action (n=x̄±s)
| Pawg | Dose/(g·kg-1) | Pleev index (mg·g-1) | Thymus index | Daim siab Performance index |
| (mg·g-1) | (mg·g-1) | |||
| Tswj pawg | - | 8.59 ± 2.12 | 2.79 ± 0.24 | 68.02 ± 4.86 |
| Qauv pawg | - | 7.17 ± 1.82 * | 2.53 ± 0.74 | 65.03 ± 7.79 |
| CTX | 0.03 ib | 5.61 ± 1.50 * | 2.20 ± 0.30 hli | 64.97 ± 3.79 |
| PEB L | 0.5 | 10.92 ± 1.69#Txhob cia siab tias yuav tau txais kev tso cai los ntawm tus tswv | 4.29 ± 0.60#Txhob cia siab tias yuav tau txais kev tso cai los ntawm tus tswv | 61.98 ± 4.50 |
| PEB M | 1 | 10.72 ± 3.09# ∆ | 4.09 ± 0.50#Txhob cia siab tias yuav tau txais kev tso cai los ntawm tus tswv | 66.01 ± 7.69 |
| PEB H | 2 | 9.57 ± 1.36∆ | 4.63 ± 0.73## ∆∆∆ | 64.78 ± 3.89 |
Cov txiaj ntsig ntawm txoj kev tshawb fawb no tau pom tias piv nrog cov pab pawg cyclophosphamide CTX, qhov spleen Performance index thiab thymus index ntawm cov nas hauv txhua koob EBPI pawg tau nce ntau (P 
2.Extend lifespan
Cov nyhuv ntawm Phellinus linteus extract ntawm cov ciaj sia taus ntawm cov tsiaj qus Caenorhabditis elegans (N2) tau pom los ntawm kev sim ua neej nyob. Nws tau pom tias ntau qhov sib txawv ntawm Phellinus linteus extract txuas ntxiv qhov nruab nrab lifespan thiab siab tshaj lifespan ntawm nematodes. Hauv particular, qhov nruab nrab lifespan ntawm nematodes kho nrog 25mg / mL SSE nce 26.41% piv nrog cov pab pawg tswj.
3.Anti-mob cancer
Fig.3.5 SVP-A-1 inhibited lub cell migration ntawm CRC (n = 6). (A) sw480 thiab (B) Caco-2 hlwb.
Daim duab 3.6 SVP-A-1 txhim kho cell apoptotic tus nqi txheeb xyuas ntawm Hoechst 33342 staining. (A) sw480 thiab (B) Caco-2 hlwb (n = 6). (200x, Scale bar: 100 μum).
Cov kev sim ntawm tes tau pom tias 0.5 thiab 1 mg / mL ntawm SVP-A-1 tuaj yeem cuam tshuam lub peev xwm ntawm tes ntawm sw480 thiab Caco-2. Piv nrog rau cov pab pawg tsis kho, sw480 thiab Caco-2 hlwb kho nrog SVP-A-1 pom muaj zog dua fluorescence thiab shrunken nuclei. Cov txiaj ntsig tau qhia tias SVP-A-1 tuaj yeem ua rau cov cell apoptosis, yog li ua rau CRC cell tuag.
4. Txo cov uric acid
Tom qab gavage nrog cov cawv extract thiab dej extract ntawm No. 5 Phellinus igniarius qauv, uric acid tus nqi ntawm pawg SHC yog 106.76 μmol / L, uas yog hais txog 40.61% qis dua cov M pawg. Tus nqi uric acid ntawm pawg SHS yog 91.37 μmol / L, uas yog kwv yees li 49.17% qis dua li ntawm pawg M. Nws tuaj yeem pom tau tias ob qho tib si cawv thiab dej extract muaj cov nyhuv txo qis uric acid hauv lub cev, thiab cov nyhuv uric acid txo qis ntawm Phellinus igniarius dej extract yog zoo dua li cov cawv extract pawg.
5. Txo cov ntshav qab zib
Daim duab 3.12 IC50 rau α-AI cov haujlwm ntawm cuaj SHFs.
Txoj kev tshawb no pom tias hom S1, S3, thiab S5 yog tag nrho cov mulberry lindera, thiab lawv cov flavonoids feem ntau muaj zog hauv inhibiting α-amylase dua li lwm hom lindera (hom S6, S7, S8, thiab S9). Cov flavonoids nyob rau hauv lub cev txiv hmab txiv ntoo (SS5) ntawm S5 muaj ib tug muaj zog muaj peev xwm inhibit α-amylase tshaj cov flavonoids nyob rau hauv lub mycelium ntawm cuaj hom ntawm lindera, qhia tau hais tias cov flavonoids nyob rau hauv lub fruiting lub cev muaj ib tug zoo dua inhibiting α-amylase.
