ODM Manufacturer Bulk Supply Pure β-Nicotinamide mononucleotide NMN Powder Factory, Manufacturer

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Manufacturer Bulk Supply Pure β-Nicotinamide Mononucleotide NMN Powder

Alias: β-Nicotinamide mononucleotide

Origin: Enzymatic synthesis

Advantages: High bioavailability; Good thermal stability; Competitive price

Appearance: White powder

Detection method: HPLC

CAS: 1094-61-7

Molecular Formula: C11H15N2O8P

Molecular Weight: 334.22g/mol

Chemical Formula:

Introduction of β-Nicotinamide mononucleotide NMN Powder

β-Nicotinamide mononucleotide (NMN) is a molecule that exists naturally in all life forms and is inherent in humans and other animals. NMN is a precursor of vitamin B3 (NAD+) and is essential for maintaining NAD+ levels in cells. NMN is involved in a variety of important biochemical reactions and is closely related to the human immune system and metabolism. Exogenous supplementation of NMN can significantly increase the NAD+ content of cells in the body.

NMN is sensitive to temperature and will decompose into nicotinamide if it exceeds a certain range. And as time goes by, water molecules in the air penetrate into NMN, and the purity of NMN decreases. Hihealth treats NMN with eutectic technology to effectively avoid NMN thermal decomposition caused by high temperature environment, and at 40°C and 75% relative humidity, it still maintains a stable purity for nearly 3 months, making NMN have a high product stability and can exert greater efficacy value.

Functions of β-Nicotinamide mononucleotide NMN Powder

1.Blood sugar management: improving insulin resistance

NMN can accelerate the glucose clearance rate induced by insulin, and the increase in the clearance rate is about 25%±7%.

2.Improve fatigue and physical function in middle-aged and elderly people

After taking NMN for 12 weeks, the elderly showed a 4.2% improvement in left hand grip strength and a 6.2% improvement in gait speed, indicating that NMN can improve muscle strength and performance in middle-aged and elderly people.

3.Lower triglyceride levels

Within 1-3 hours of taking NMN, the triglyceride content in the volunteers' blood decreased by 75%, which has a significant lipid-lowering effect.

4.Bone health, reducing bone loss

Effects of NMN on BMD and bone structural properties of the femurs. (A) Representative three-dimensional reconstructed images derived by micro-CT. (B) NAD+ levels in femurs were measured. (C) Quantitative analysis of Trabecular volumetric BMD in 3 individual groups of rats. (D) Quantitative analysis of BVF in 3 individual groups of rats. (E) Quantitative analysis of trabecular number in 3 individual groups of rats. (F) Quantitative analysis of trabecular thickness in 3 individual groups of rats. (G) Quantitative analysis of trabecular separation in 3 individual groups of rats. Data were expressed as mean ± SEM (n = 10 per group). **P < .01 vs. the Control group, ⁎⁎⁎P < .001 vs. the Control group, #P < .05 vs. the AlCl3 group, ##P < .01 vs. the AlCl3 group.

NMN treatment significantly alleviated bone injuries by decreasing bone loss, suppressing oxidative stress as well as inhibiting Thioredoxin-interacting protein (TXNIP)-NLRP3 inflammasome pathway and pro-inflammatory cytokine production in vivo and in vitro.

5.Improve retinal dysfunction

NMN therapy for the suppression of cardiovascular diseases-mediated retinal ischemic dysfunction.

6.Anti-aging: reducing stem cell aging and restoring mitochondrial function

Picture: Nicotinamide mononucleotide (NMN) repletion improves mitochondrial function and prevents mesenchymal stem cell (MSC) replicative senescence.（left）The nicotinamide adenine dinucleotide (NAD+)/Sirt3 signaling pathway is up-regulated in late passage mesenchymal stem cells (LP MSCs) treated by exogenous nicotinamide mononucleotide (NMN). （right）

Supplementation of NMN can increase the activity of the longevity protein sirtuin 3 (Sirt3), reduce the aging of stem cells, and restore mitochondrial function.