Alias: L-Ergothioneine
Origin: Biosynthesis
Specification: 5%-99% Ergothioneine
Advantages: Customized specifications; High bioavailability; Good light stability; Competitive price
Appearance: White crystalline powder, no obvious odor
Detection method: HPLC
CAS: 497-30-3
Molecular formula: C9H15N3O2S
Molecular weight: 229.3g/mol
Chemical formula:
Ergothioneine (EGT) is a natural rare chiral amino acid antioxidant. In 1909, it was first discovered in ergot fungi by French pharmacist Charles Tanret and named after it. Bruce Ames, a member of the American Academy of Sciences, once proposed in the Proceedings of the National Academy of Sciences that ergothioneine is a true longevity nutrient. However, ergothioneine cannot be synthesized by the human body and can only be obtained through dietary intake, of which edible fungi are its main dietary source.
The main problem of ergothioneine at present is its light instability, which is easy to decay and produce odor under light conditions. Based on the efficient fermentation synthesis process + efficient separation and purification process + liposome encapsulation technology, Hihealth has greatly improved the light stability of ergothioneine, making it not easily decomposed by light.
| Content | 5%-99% |
| Photostability | Optimized by 25.1% |
1.Antioxidant
Figure 1
Figure 2
Figure 3
Figure 1: When used at equimolar concentrations, ergothioneine is more effective than coenzyme Q10 in inhibiting lipid peroxide formation
Figure 2: The peroxide free radical (ROO-) scavenging energy of ergothioneine is 5.5 times that of glutathione
Figure 3: The hydroxyl free radical (OH.) of ergothioneine is 60% higher than that of trolox.
2.Anti-aging
For mice given ergothioneine, median and average survival ages increased by 16% and 21%, respectively, and the average age at which 90% of the mice died increased by 29% compared to that in the control group.
3.Improve cognition
The discrimination index (DI), which was calculated to compare object recognition ability, was significantly higher in the ergothioneine group than in the control group at 24 and 88 weeks of age, suggesting that oral intake of ergothioneine enhanced aging-mice recognition memory.
4.Protect against UV light aging
Figure 1
Figure 2
Figure 1：Ergothioneine (EGT) suppressed MMP-1 and IL1β expression but enhanced the procollagen expression in HSF cells.
Figure 2：Ergothioneine(EGT) suppressed UVA-induced ROS production in HSF cells
Ergothioneine ameliorated UVAinduced skin aging and is a useful food supplement for skin care products.. UVA-induced collagenolytic matrix metalloproteinase- 1(MMP-1)activation and type I procollagen were found to be inhibited by Ergothioneine treatments. Moreover, Ergothioneine mitigated UVA-induced ROS generation. Ergothioneine can improve skin aging caused by ultraviolet radiation.
5.Inhibit inflammatory factors
The levels of inflammatory cytokines in keratinocytes were significantly decreased in the 1mM ergothioneine (EGT) alone treatment group and the 10mM EGT alone treatment group.
6.Improve cardiovascular health
Ergothioneine was most strongly associated with a health-conscious food pattern and was an independent predictor of reduced coronary heart disease, stroke, cardiovascular mortality, and total mortality, and could reduce mortality in patients with cardiovascular disease and the risk of cardiovascular disease in healthy people.
7.Improve sleep quality
Figure：Changes in EEG-derived parameters in participants
A 20 mg EGT or placebo capsule was ingested daily for 4 weeks by volunteers with reported high anxiety and sleep complaints. A survey showed that EGT significantly ameliorates sleeping difficulties. Electroencephalograph measurements showed that EGT intake increases the N2 stage, while decreasing the N1 stage in non-REM sleep and the frequency of waking after sleep onset.
