Advantages:
Better performance in hot environment; Light decomposition resistant; Good photothermal stability; Reduce the loss of α-Thioctic Acid
Appearance:
Brown loose powder
Detection Method:
HPLC
Bulk Density:
0.26g/mL
Advantages:
Competitive price; Advanced green technology
Graph Description:
Yellow Powder
Detection Method:
HPLC
Bulk Density:
0.21g/mL
1.Strengthen liver function
Lipoic acid has the ability to enhance liver activity, so it is also used as an antidote for food poisoning or metal poisoning.
Figure 1. Effect of α-lipoic acid on lipid metabolism in rats. (A) Oil Red-O staining of a liver section (magnification, 400×). (B) Plasma triglyceride levels. (C) Hepatic triglyceride contents. (D) Plasma high-density lipoprotein levels. (E) Plasma low-density lipoprotein levels. (F) Plasma cholesterol levels. (G) Hepatic cholesterol contents. CON: Control diet, LA: Control diet+ alpha-lipoic acid. Values are expressed as mean ± SEM, n = 12 in each group, * p < 0.05.
As shown in Figure 1, the Oil Red-O staining results show that the α-Lipoic Acid (LA ) group had fewer lipid droplets than the control group (Figure 1A). Correspondingly, adding dietary α-lipoic acid markedly decreased the plasma triglyceride level (Figure 1B) and hepatic triglyceride content (Figure 1C).α-Lipoic Acid Alleviates Hepatic Lipid Deposition.
2.Recover from fatigue
Since lipoic acid can increase the energy metabolism rate and effectively convert the food eaten into energy, it can quickly eliminate fatigue and make the body feel less tired.
3.Improve dementia
The lipoic acid molecules are quite small, so it is one of the few nutrients that can reach the brain. It also continues to have antioxidant activity in the brain and is considered to be quite effective in improving dementia.
Neuropsychological testing before and after treatment with -lipoic acid
Fig. 1. MMSE before and after therapy with lipoic acid (treatment start: day 0)
600 mg α-lipoic acid was given daily to nine patients with Alzheimer’s disease (AD) and related dementias (receiving a standard treatment with acetylcholinesterase inhibitors) in an open study over an observation period of, on avarage, 337±80 days. The treatment led to a stabilization of cognitive functions in the study group, demonstrated by constant scores in two neuropsychological tests (mini-mental state examination: MMSE and AD assessment scale, cognitive subscale: ADAScog).
4.Beauty and anti-aging
Lipoic acid has amazing antioxidant effects, which can remove active oxygen components that cause skin aging. It is also smaller than vitamin E molecules, and is both water-soluble and fat-soluble, so it is easily absorbed by the skin. (CoQ10, which is widely used in Taiwan, is fat-soluble, and its biggest disadvantage is that it is not easily absorbed.) It is especially effective for dark circles, wrinkles, and spots. In addition, strengthening the metabolic function will improve the body's blood circulation, improve the dullness of the skin, and reduce the pores, making the skin delicate and enviable. Therefore, lipoic acid is also the No. 1 anti-aging nutrient in the United States, on par with Q10.
5.Protect your body
In Europe, research has been conducted specifically on lipoic acid as an antioxidant, and it has been found that lipoic acid can protect the liver and heart from damage, inhibit the occurrence of cancer cells in the body, and relieve allergies, arthritis, and asthma caused by inflammation in the body.
Our data indicate that the aging rat heart is under increased mitochondrial-induced oxidative stress, which is significantly attenuated by lipoic acid supplementation. Results show that lipoic acid treatment significantly reversed the age-related increase in oxidant production back to levels not different from the young.And dietary supplementation of LA leads to restoration of ascorbate back to the levels found in the young. What’s more, LA supplementation significantly lowered the age-related accumulation of 8-oxo-dG in hearts from old rats.
6.Weight manager
Figure 1. Mean body weight differences between ALA treatment and placebo(left)
Figure 2. Mean BMI differences between ALA treatment and placebo (right)
Alpha-lipoic acid treatment coincided with a statistically significant 1.27 kg (confidence interval = 0.25 to 2.29) greater mean weight loss compared with the placebo group. A significant overall mean BMI difference of -0.43 kg/ m2 (confidence interval = -0.82 to -0.03) was found between the ALA and placebo groups. Alpha-lipoic acid treatment showed small, yet significant short-term weight loss compared with placebo.
7.Blood sugar manangement
Fig. 1. Treatment induced changes in insulin sensitivity as measured by the glucose clamp method: percent of subjects in each group showing an improvement of MCR; *p <0.05.(left)
Fig. 2. Absolute effects of active versus placebo intervention on MCR. As there were no differences between the three active treatment groups, they were combined as “active treatment” (see text); *p <0 .05.(right)
The effects of a 4-week oral treatment with a-lipoic acid were evaluated in a placebo-controlled, multicenter pilot study to determine see whether oral treatment also improves insulin sensitivity. After treatment, glucose uptake improved significantly more often in those groups that had active treatment (Fig. 1). While the MCR decreased by 210% in the placebo group, insulin sensitivity increased by 115% after 600 mg, 114% after 1200 mg and 122% after 1800 mg. Therefore, all patients receiving a-lipoic acid were combined in the “active” treatment group. When this combined active group was compared to the placebo treated diabetics, there was a significant difference in the change of MCR: while it decreased by 210% in the placebo group, it increased by 117% after a-lipoic acid (active vs. placebo 127%, p < .01, Fig. 2).
