Alias: Ceramides，N-Acylsphingosine
Origin: Rice Bran Oil Extract
Specification: AN; NP
Advantages: Customized water solubility specifications; High bioavailability; Good stability; Competitive price
Appearance: White powder
Detection method: HPLC
CAS: 100403-19-8
Molecular Formula: C24H47NO3
Molecular Weight: 397.63g/mol
Chemical Formula:
Ceramide is formed by covalent condensation of sphingosine and long-chain fatty acids with carbon numbers of 12 to 30. As the main component of intercellular lipids in the stratum corneum of the skin, it accounts for about 50% of the lipids in the stratum corneum. It plays an important role in the formation of the epidermal stratum corneum and has the functions of maintaining the skin barrier, moisturizing, anti-aging, and whitening.
The difficulty in the application of ceramide is that it is difficult to dissolve in water and oil, and its application in cosmetics and functional foods is limited. After it is added to the product, flocculation and agglomeration are prone to occur under acidic and hot conditions, and the overall stability is poor. Hihealth uses liquid crystal emulsification technology to make it have better water solubility and remain stable without precipitation under acidic and hot conditions, which is more suitable for the multi-dosage application of cosmetics and functional foods.
1.Improves skin barrier
All the parameters related to skin barrier function showed significant changes (p < 0.001) after three-month supplementation of rice ceramides . Significant reduction (p < 0.001) in Transepidermal water loss was observed in cheek, neck, and arm, with a reduction of 36.9%, 47.1%, and 39.2% respectively. Consequently, stratum corneum hydration was also significantly improved (p < 0.001) towards the end of this study, with 22.8%, 16.3%, and 31.9% improvement at the cheek, neck, and arm area, respectively. Likewise, sebum production was significantly improved (p < 0.001) by 115.3%, 183.6%, and 219.1%, at the area of cheek, neck, and arm respectively.
2.Tightens skin and increases skin elasticity
Skin firmness and elasticity of cheek, neck, and arm areas were all significantly improved (p < 0.01) after three-month of rice ceramides supplementation .
Viscoelasticity unit (VEU) of cheek area was improved from 0.562 ± 0.134 to 0.662 ± 0.131, equivalent to 17.8% improvement. Similarly, VEU of neck was improved from 0.775 ± 0.065 to 0.829 ± 0.073, equivalent to 7% improvement. VEU of arm was improved by 4.1%, from 0.785 ± 0.042 to 0.817 ± 0.056 at the end of this study. Wrinkle severity as assessed by WSRS also showed a significant reduction (p < 0.01) from 1.92 ± 0.89 to 1.60 ± 0.78, which is equivalent to 16.7%.
3.Whitening and sun protection
Both MI and EI of participants were significantly reduced (p < 0.001) in all the three areas in the end of this study. The reduction of MI in the area of cheek, neck, and arm were 13.2%, 17.7%, and 15.2%, respectively. Likewise, EI of participants was significantly reduced (p < 0.001) by 15.7%, 15.2%, and 12.5% at the area of cheek, neck, and arm respectively.
4.Improve skin roughness
After taking 1.2 mg of ceramide for 14 days, skin roughness can be significantly improved and skin pores can be refined.
5.Improve skin itching and atopic dermatitis
After taking 1.2 mg of ceramide for 8 weeks, the degree of skin itching and skin atopic dermatitis were significantly reduced.
6.Improve insulin resistance
After taking 1.2 mg of ceramide for 8 weeks, the degree of skin itching and skin atopic dermatitis were significantly reduced.
7.Improve insulin resistance
Ceramides significantly improved glucose tolerance, reduced the concentrations of serum glucose and glycosylated hemoglobin. The intervention of ceramides significantly reduced serum glucose levels at 60 min, and the glucose AUC in rats treated with ceramides reduced by 12.7 %,compared to that of the model group. And , the intervention of Cer exhibited a reducing trend in the HOMA-IR index.Notably, the intervention of ceramides significantly reduced the levels of glycated hemoglobin by 9.3%, compared to the model group.
8.Improve atherosclerosis
The formation of atherosclerosis is related to lipid vesicular cells. The accumulation of oxidized low-density lipoprotein in macrophages is taken up by scavenger receptors, thus forming lipid vesicular cells. The accumulation of lipid vesicular cells under the endothelium of the arterial wall forms a block, which becomes a sign of atherosclerotic plaques. Oxidized low-density lipoprotein can lead to increased expression of scavenger receptor CD36. Ceramide can reduce CD36 expression.
