Alias: (Ubiquinone，UQ) Ubiquinone 10, Ubiquinone, Vitamin Q (Ubiquinone，UQ)
Origin: Microbial fermentation extraction
Specification: 10%-98%COQ10
Advantages: Customized water solubility specifications; High bioavailability; Microbial fermentation process, easy to absorb; high biological activity and safety; Competitive price
Appearance: Yellow to orange powder or crystallization
Locality of growth: China
Detection method: HPLC
CAS: 303-98-0
Molecular Formula: C59H90O4
Molecular Weight: 863.36 g/mol
Chemical Formula:
Coenzyme Q10 is a fat-soluble quinone compound widely found in organisms. It participates in the electron transfer in the biological oxidative respiratory chain, promotes the production of ATP, and maintains the body's metabolism and energy supply. At the same time, it is also an important antioxidant and nonspecific immune enhancer. Under normal circumstances, the human body can synthesize coenzyme Q10, but the synthesis process is complex and is affected by factors such as genes, age, nutrition, underlying diseases and drugs. Studies have shown that the coenzyme Q10 content in a person's body is relatively low at birth, and reaches a peak at around 20 years old, but the synthesis capacity gradually decreases after the age of 25. The coenzyme Q10 content in the myocardium of a 77-year-old man is more than 50% lower than that of a 20-year-old young person. Coenzyme Q10 deficiency can cause fatigue in the body, and long-term severe deficiency can even cause heart failure.
95% of coenzyme Q10 in human blood exists in the form of ubiquinol. Ubiquinone needs to be converted into ubiquinol to be active, that is, after oxidized coenzyme Q10 (ubiquinone) enters the cell mitochondria, it needs to accept the hydrogen ions of NADH and become reduced coenzyme Q10 (ubiquinol) to play a physiological role in the mitochondria. However, the chemical properties of reduced coenzyme Q10 are unstable, the technology is difficult, and the raw material production cost is high. Oxidized coenzyme Q10 has poor solubility and low absorption rate (the melting point of coenzyme Q10 is 20℃ higher than body temperature). In fact, only about 1mg can be absorbed after taking 100mg of powdered coenzyme Q10. Nuozhong has greatly improved the water solubility and bioavailability of coenzyme Q10 raw materials by using its mature encapsulation technology.
1.Heart Health
A meta-analysis study on the effectiveness and safety of coenzyme Q10 in relieving heart failure. The study included 27 randomized controlled trials with 3,222 subjects. The results showed that the mortality rate of the coenzyme Q10-assisted intervention group was lower than that of the control group, indicating that coenzyme Q10 can reduce the mortality rate and NYHA cardiac function classification of patients with heart failure, improve ejection fraction and 6MWT, and no obvious adverse reactions occurred.
| Table 1 Basic characteristics of included studies | |||||
| Included studies | Group | n Example | Interventions | Treatment course/month | Outcome Measures |
| Permanetter | Control | 10 | Conventional treatment + placebo | 4 | ③ |
| 1992 | Experiment | 15 | Conventional treatment + Coenzyme Q10 33.3mg, 3 times a day | ||
| Morisco | Control | 322 | Conventional treatment + placebo | 12 | ① |
| 1993 | Experiment | 319 | Conventional treatment + Coenzyme Q10 50mg, 2-3 times a day | ||
| Morisco | Control | 6 | Conventional treatment + placebo | 1 | ②④ |
| 1994 | Experiment | 6 | Conventional treatment + Coenzyme Q10 50mg, 3 times a day | ||
| Hofman-Bang | Control | 79 | Conventional treatment + placebo | 3 | ①②④ |
| 1995 | Experiment | 79 | Conventional treatment + Coenzyme Q10 100mg, 1 time a day | ||
| Watson | Control | 30 | Conventional treatment + placebo | 3 | ①② |
| 1999 | Experiment | 30 | Conventional treatment + Coenzyme Q10 33mg, 3 times a day | ||
| 牛敏芬 | Control | 72 | Conventional treatment + placebo | 3 | ① |
| 1999 | Experiment | 89 | Conventional treatment + Coenzyme Q10 30-60mg, 1 time a day | ||
| Munkholm | Control | 11 | Conventional treatment + placebo | 3 | ② |
| 1999 | Experiment | 11 | Conventional treatment + Coenzyme Q10 100mg, 2 times a day | ||
2.Exercise recovery
A study titled “Reducing exercise-induced muscular injury in kendo athletes with supplementation of coenzyme Q10” showed that after supplementing with coenzyme Q10, serum creatine kinase (CK) activity and myoglobin (Mb) concentration were significantly increased, while serum CK (3d), Mb (3d) and lipid peroxides (3d and 5d) were lower than those in the placebo group, indicating that coenzyme Q10 supplementation can help reduce muscle damage caused by strenuous exercise.
3.Reduce fatigue
A meta-analysis of 13 randomized controlled trials (total 1,126 participants) using a random-effects model showed that the CoQ10 group showed a statistically significant reduction in fatigue scores compared with the placebo group, and the direction of the treatment effect was consistent between healthy and diseased participants.
Results of the present study revealed that BA possess a dose dependent antiulcer effect against different experimental models. It showed different degree of inhibition of the ulcer score towards different ulcerogenic agents. The ulcer score against various ulcer inducing agents viz., pyloric ligation, ethanol/HCl, (acute and chronic) acetylsalicylic acid, indomethacin and cold restraint stress, was inhibited by 39%, 38%, 51%, 31%, 37% and 42% respectively at 250 mg/kg.
4.Antioxidant properties
CoQ10 significantly reduced the increase in oxidative and nitrative stress markers and inflammatory markers in a dose-dependent manner.
5.Lower elevated blood pressure
The systolic blood pressure in the control group became elevated quite rapidly with age. The blood pressures of the CoQ10-treated groups were significantly lower than that of the control group after 18 weeks of age.
6.Enhances immunity
The marked suppression of the humoral hemolytic, primary immune response as afunction of age of the mice is demonstrated. the hemolytic antibodylevel in 22 month old mice is less than 50% of the level obtained in 10 week old mice.The profound hemolytic antibody depression in old mice can be partly reversedby a single intravenous administration of coenzyme Q10.
7. Anti-aging
CoQ10 can overcome mitochondrial dysfunction by enhancing MMP. Moreover, CoQ10 treatmentprotects cutaneous energetic capacity against UV irradiation in an overcompensatory manner.
