Alias: Iron fan, yellow mulberry, thorn mulberry
Origin: Dried leaves of mulberry tree
Specification: 1-Deoxynojirimycin and Mulberry leaf flavonoids
Advantages: Customized water solubility specifications; High bioavailability; Good thermal stability; Competitive price
Appearance: Brown powder with mulberry leaf flavor
Locality of growth: China
Detection method: HPLC(1-DNJ) and UV(flavonoids)
CAS: 73285-50-4
Molecular Formula: C6H13NO4.ClH
Molecular Weight: 199.63g/mol
Chemical Formula:
Mulberry leaf is a traditional Chinese medicinal and edible raw material with a long history of use. In the Compendium of Materia Medica, Li Shizhen called mulberry leaf "immortal grass", which has the reputation of "ginseng heat tonic, mulberry leaf clear tonic". Mulberry leaf has extremely high pharmacological value, among which mulberry leaf flavonoids and alkaloids are the main active ingredients, and are widely used in hypoglycemic, anti-sugar, and weight management products.
There are two pain-points in the application of mulberry leaf:
1.Mulberry leaf flavonoids have poor water solubility and low absorption and utilization;
2.Mulberry leaf alkaloids have a short half-life of only 2 hours in the human body,
which makes the duration of mulberry leaf effect short. These problems have greatly limited the further application of mulberry leaf.
1. Lowers blood sugar, beneficial for diabetic patients
Mulberry leaf crude extract, DNJ and flavonoids can significantly promote cellular sugar uptake and improve cellular insulin resistance (left). Mouse experimental models show that mulberry leaves can improve ob/ob mouse glucose tolerance, reduce fasting blood sugar levels in mice, significantly reduce fasting insulin levels, and improve insulin resistance (right).
2. Anti-obesity and weight management
Mulberry leaves significantly alleviated adiposity of DIO mice including reducing body weight gain, fat accumulation and fasting blood glucose, and improving insulin sensitivity.
3. Lower blood lipids
The plasma TG concentration and Total cholesterol in mulberry leaves treatment groups was significantly reduced compared with that of HF group
4. Improve liver and kidney function
DIO mice had elevated serum AST and mulberry leaves significantly (P < 0.05) restored its concentration . In addition, serum LDH was reduced after mulberry treatment. In addition, mulberry leaves significantly (P < 0.05) reduced serum CREA concentration and the BUN/CREA ratio.
