The changes in the blood pressure, heart rate, creatinine, BUN, glucose and C-reactive protein (CRP) of the serum were determined in the treated animals. l-citrulline significantly (p < 0.001) inhibited the changes in the blood pressure and heart rate in CsA-treated as well as it was able to reduce blood pressure in non-treated group significantly (p < 0.01).
Oral l-citrulline supplementation improved ICP/MAP and SM/collagen ratios and increased NOx. Therefore, oral l-citrulline supplementation might be a useful novel therapy for acute arteriogenic Oral l-citrulline supplementation improves erectile function in rats with acute arteriogenic erectile dysfunction.
Mice orally supplemented with L-citrulline had significantly higher gastrocnemius and biceps femoris muscle mass. Although not statistically significant, L-citrulline prolonged the swimming time to exhaustion. Supplementation with L-citrulline upregulates skeletal muscle PGC-1 alpha levels resulting in higher skeletal muscle weight that improves time to exhaustion during exercise.
The weight of male OTCD patients improved by +0.79 SD, and the ammonia level decreased by a mean of 44.3 mol/L in all patients. The protein intake of all patients and of male OTCD patients increased by 0.14 g/kg/day and 0.17 g/kg/day, respectively. l-Citrulline effectively reduced ammonia level, increased protein intake, and improved weight gain in UCD patients.