1.Improve immunity
Boletus polysaccharides can increase the immune organ index of mice and improve the immune function of mice; increase the phagocytic index and phagocytic coefficient of mice, and have a certain enhancing effect on the nonspecific immune function of mice; increase the content of cytokines IL-2 and IFN-γ in mouse serum and enhance the cellular immune function of mice.
2.Antitumor activity
抑制率:Inhibition rate
子实体多糖:Fruiting body polysaccharide
菌丝体胞内多糖:Mycelium intracellular polysaccharide
菌丝体胞外多糖:Mycelium extracellular polysaccharide
菌丝体胞内多糖:Mycelium intracellular polysaccharide
菌丝体胞外多糖:Mycelium extracellular polysaccharide
Boletus polysaccharide has an inhibitory effect on Hela cells, and the inhibition rate is dose-dependent with the administration concentration. It has certain anti-tumor activity.
3.Lower blood sugar
The study found that the phagocytic activity of RAW264.7 cells was significantly enhanced in the concentration range of 100~1000ug/mL, and the secretion of NO, IL-6, and TNF-α was significantly promoted. At the same time, the expression levels of iNOS, IL-6, and TNF-α mRNA were also significantly increased.
Note: ⅳ Whole fruiting body polysaccharide; ⅴ Cap polysaccharide; ⅵ Stem polysaccharide
The blood glucose and insulin levels of diabetic mice treated with Boletus polysaccharide were significantly lower than those in the model group, indicating that Boletus polysaccharide has a significant blood glucose-lowering effect.
4. Antioxidant
Antioxidant activities of Boletus edulis were 85.7%.Boletus edulis showed higher scavenging abilities on DPPH radicals, and Scavenging abilities were 88.8%. Boletus edulis was effective in antioxidant properties
5.Anti-fatigue and sports performance improvement
Tab.1 Comparison of body mass and exhausting exercise time of rats in each group
| Group | Quantity/pcs | Body mass/g | Exhaustive exercise time/time |
| Quiet Group | 10 | 435.77±27.38 | - |
| Sports Group | 10 | 358.78±23.13* | 55.38±11.08 |
| Exercise medication group | 10 | 399.36±26.62** | 75.38±18.03* |
Nobe: *means compared with quiet group, P<0.05,**means compared with the exercise group, P<0.0s.
Tab.2 Comparison of Na'/k' _ATP,Ca2/Mg2 _ATP activity in each group of rats
| Group | Quantity/pcs | /(U.mg-1) | |
| Na'/k' _ATP | Ca2/Mg2 _ATP | ||
| Quiet Group | 10 | 5.64±0.37 | 8.31±0.67 |
| Sports Group | 10 | 2.28±0.21* | 4.25±0.22* |
| Exercise medication group | 10 | 4.35±0.51** | 6.01±0.56** |
Nate: *compared with the quiet group, P<0.05; *Compared with the exercise group, P<0.05.
Boletus griseus polysaccharide can inprove the body mass, the last exhaustive exercise time, Na + /K+ -ATPase and Ca2+ /Mg2+ -ATP in skeletal muscle.The polysaccharide of B. griseus can improve the activity of ATPase, maintain the normal distribution of ions inside and outside the cell membrane。And improve its movement ability.
6.Liver protection
Boletus edulis polysaccharides significantly prevent the increase serum ALT and AST caused by CCl4 in mice. Boletus edulis polysaccharides could also markedly increase the activities of liver SOD,GSH-Px，GSH. Boletus edulis polysaccharides have protective effect on acute liver injury.
